Chicken Bubble Biscuit Bake Casserole

By :

Laura

March 7, 2026

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How to make Chicken Bubble Biscuit Bake Casserole

Chicken Bubble Biscuit Bake Casserole is a fun and comforting dish that combines savory flavors with that delightful biscuit texture. Perfect for family dinners or potlucks, this casserole is both hearty and easy to make. Here’s how you can whip up this mouthwatering dish in your kitchen.

Ingredients

3 cups cooked shredded chicken
1 cup diced cooked ham or bacon
2 cans condensed cream of chicken soup (10.5 ounces each)
1 1/2 cups milk
1 cup sour cream
2 teaspoons garlic powder
1 teaspoon onion powder
1 teaspoon dried parsley plus extra for garnish
1/2 teaspoon salt or to taste
1/2 teaspoon black pepper
2 cups shredded cheddar cheese, divided
2 cans refrigerated buttermilk biscuit dough (16.3 ounces each), cut into quarters
2 tablespoons melted butter

Directions

Preheat the oven to 350°F (175°C) and lightly grease a 9×13 inch baking dish with nonstick spray or butter.
In a large mixing bowl, whisk together the condensed cream of chicken soup, milk, and sour cream until smooth and creamy.
Stir in the garlic powder, onion powder, dried parsley, salt, and black pepper until the seasonings are evenly distributed.
Fold in the shredded chicken, diced ham or bacon, and 1 cup of the shredded cheddar cheese. Spread the mixture evenly into the prepared baking dish.
Open the cans of refrigerated biscuit dough, separate the biscuits, and cut each biscuit into 4–6 small pieces.
Scatter the biscuit pieces evenly over the creamy chicken mixture, gently pressing some pieces slightly into the sauce and leaving others on top for crispier, golden bubbles.
Sprinkle the remaining 1 cup of shredded cheddar cheese evenly over the top of the biscuit pieces.
Cover the baking dish loosely with aluminum foil and bake for 25 minutes to allow the biscuits to cook through.
Remove the foil, brush the tops of the biscuits with the melted butter, and return the casserole to the oven for another 10–15 minutes, or until the biscuits are puffed, deeply golden, and the sauce is bubbling around the edges.
Remove the casserole from the oven and let it rest for 5–10 minutes so the sauce can thicken slightly.
Sprinkle with additional dried or fresh chopped parsley, slice or scoop into portions, and serve warm.

Why You’ll Love This Chicken Bubble Biscuit Bake Casserole

This Chicken Bubble Biscuit Bake Casserole is packed with flavors that melt in your mouth. The combination of tender chicken, creamy sauce, and fluffy biscuits creates a comfort food experience that is hard to resist. It’s a one-dish meal that can feed a crowd, making it ideal for family gatherings or casual get-togethers with friends. The simplicity of this recipe allows anyone, regardless of cooking skills, to create a delicious meal.

Nutritional Benefits

This casserole has several nutritional benefits, thanks to its wholesome ingredients.

Protein-Packed: The chicken and ham provide a great source of protein, essential for muscle repair and growth.
Dairy Goodness: Sour cream and cheddar cheese contribute calcium, which is vital for strong bones and teeth.
Balanced Flavors: The addition of herbs and spices, like garlic and parsley, not only enhances flavor but also adds some nutritional benefits such as antioxidants.

Overall, you can enjoy this casserole as part of a balanced meal while savoring every bite.

What to Serve With Chicken Bubble Biscuit Bake Casserole

Pairing this casserole with the right sides can elevate your dining experience. Here are some ideas for what to serve with it:

How to Store Chicken Bubble Biscuit Bake Casserole

Storing leftovers from this Chicken Bubble Biscuit Bake Casserole is easy. Follow these simple steps:

Let it Cool: Allow the casserole to cool completely before storing.
Use an Airtight Container: Transfer leftovers to an airtight container. This will help preserve freshness and prevent odors from other foods absorbing into the casserole.
Refrigerate: Store in the fridge for up to 3-4 days. If you want to keep it for longer, consider freezing it.
Freezing Tips: For freezing, wrap the casserole tightly in plastic wrap, then in aluminum foil. It can be frozen for up to 2-3 months.

When ready to enjoy again, simply thaw in the refrigerator overnight and reheat in the oven until hot throughout.

Tips and Mistakes to Avoid

When making this casserole, here are some tips to keep in mind:

Don’t Skip the Resting Time: Letting the casserole sit after baking allows the sauce to thicken, ensuring each serving holds together nicely.
Avoid Overmixing: Be careful not to overmix the biscuit pieces into the creamy mixture to keep the texture light and fluffy.
Customize: Feel free to adjust the ingredients based on what you have available. Substituting turkey for chicken or adding vegetables like peas or carrots can enhance the dish.

Variations

To add a personal touch or accommodate different dietary preferences, try some of these variations:

Vegetarian Option: Replace chicken and ham with sautéed mushrooms, bell peppers, and zucchini for a hearty veggie mix.
Spicy Kick: Add diced jalapeños or a dash of hot sauce to the mixture to bring some heat.
Different Cheeses: Swap out cheddar cheese for mozzarella or pepper jack to create your own flavor profile.

FAQs

1. Can I use rotisserie chicken for this recipe?
Yes, using rotisserie chicken is a great shortcut to save time. Just shred the chicken and mix it into the casserole.

2. Can I prepare this casserole ahead of time?
Absolutely! You can assemble it the night before and store it covered in the fridge. Just bake it the next day, adding a few extra minutes to the cooking time if it’s cold from the fridge.

3. How do I know when the casserole is done?
The casserole is ready when the biscuits are puffed and golden brown, and the sauce is bubbling around the edges. A toothpick inserted into the center should come out clean.

In conclusion, Chicken Bubble Biscuit Bake Casserole is an easy and flavor-filled dish to make. It’s perfect for busy nights or when you want something comforting and delicious. Enjoy making and sharing this wonderful recipe with family and friends!

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Chicken Bubble Biscuit Bake Casserole